Mitochondrial LON Protease-Dependent Degradation of Cytochrome c Oxidase Subunits under Hypoxia and Myocardial Ischemia

The mitochondrial ATP dependent matrix protease, Lon, is involved in the maintenance of mitochondrial DNA nucleoids and degradation of abnormal or misfolded proteins. The Lon protease regulates mitochondrial Tfam (mitochondrial transcription factor A) level and thus modulates mitochondrial DNA (mtDN...

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Publicado no:Biochim Biophys Acta
Main Authors: Sepuri, Naresh B.V., Angireddy, Rajesh, Srinivasan, Satish, Guha, Manti, Spear, Joseph, Lu, Bin, Anandatheerthavarada, Hindupur K., Suzuki, Carolyn K., Avadhani, Narayan G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5507603/
https://ncbi.nlm.nih.gov/pubmed/28442264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbabio.2017.04.003
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