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Protein Kinase A-mediated Phosphorylation Modulates Cytochrome c Oxidase Function and Augments Hypoxia and Myocardial Ischemia-related Injury

We have investigated the effects of hypoxia and myocardial ischemia/reperfusion on the structure and function of cytochrome c oxidase (CcO). Hypoxia (0.1% O(2) for 10 h) and cAMP-mediated inhibition of CcO activity were accompanied by hyperphosphorylation of subunits I, IVi1, and Vb and markedly inc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Prabu, Subbuswamy K., Anandatheerthavarada, Hindupur K., Raza, Haider, Srinivasan, Satish, Spear, Joseph F., Avadhani, Narayan G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2005
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4271455/
https://ncbi.nlm.nih.gov/pubmed/16303765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M507741200
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