Autophagy mitigates ethanol-induced mitochondrial dysfunction and oxidative stress in esophageal keratinocytes

During alcohol consumption, the esophageal mucosa is directly exposed to high concentrations of ethanol (EtOH). We therefore investigated the response of normal human esophageal epithelial cell lines EPC1, EPC2 and EPC3 to acute EtOH exposure. While these cells were able to tolerate 2% EtOH for 8 h...

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Vydáno v:PLoS One
Hlavní autoři: Chandramouleeswaran, Prasanna M., Guha, Manti, Shimonosono, Masataka, Whelan, Kelly A., Maekawa, Hisatsugu, Sachdeva, Uma M., Ruthel, Gordon, Mukherjee, Sarmistha, Engel, Noah, Gonzalez, Michael V., Garifallou, James, Ohashi, Shinya, Klein-Szanto, Andres J., Mesaros, Clementina A., Blair, Ian A., Pellegrino da Silva, Renata, Hakonarson, Hakon, Noguchi, Eishi, Baur, Joseph A., Nakagawa, Hiroshi
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7510980/
https://ncbi.nlm.nih.gov/pubmed/32966340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0239625
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