Autophagy mitigates ethanol-induced mitochondrial dysfunction and oxidative stress in esophageal keratinocytes

During alcohol consumption, the esophageal mucosa is directly exposed to high concentrations of ethanol (EtOH). We therefore investigated the response of normal human esophageal epithelial cell lines EPC1, EPC2 and EPC3 to acute EtOH exposure. While these cells were able to tolerate 2% EtOH for 8 h...

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Publicado en:PLoS One
Autores principales: Chandramouleeswaran, Prasanna M., Guha, Manti, Shimonosono, Masataka, Whelan, Kelly A., Maekawa, Hisatsugu, Sachdeva, Uma M., Ruthel, Gordon, Mukherjee, Sarmistha, Engel, Noah, Gonzalez, Michael V., Garifallou, James, Ohashi, Shinya, Klein-Szanto, Andres J., Mesaros, Clementina A., Blair, Ian A., Pellegrino da Silva, Renata, Hakonarson, Hakon, Noguchi, Eishi, Baur, Joseph A., Nakagawa, Hiroshi
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2020
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7510980/
https://ncbi.nlm.nih.gov/pubmed/32966340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0239625
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