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Chemical strategies to overcome resistance against targeted anticancer therapeutics

Emergence of resistance is a major factor limiting the efficacy of molecularly targeted anticancer drugs. Understanding the specific mutations, or other genetic or cellular changes, that confer drug resistance can help in the development of therapeutic strategies with improved efficacies. Here, we o...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Pisa, Rudolf, Kapoor, Tarun M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7510053/
https://ncbi.nlm.nih.gov/pubmed/32694636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0596-8
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