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Chemical strategies to overcome resistance against targeted anticancer therapeutics

Emergence of resistance is a major factor limiting the efficacy of molecularly targeted anticancer drugs. Understanding the specific mutations, or other genetic or cellular changes, that confer drug resistance can help in the development of therapeutic strategies with improved efficacies. Here, we o...

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Pubblicato in:Nat Chem Biol
Autori principali: Pisa, Rudolf, Kapoor, Tarun M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7510053/
https://ncbi.nlm.nih.gov/pubmed/32694636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0596-8
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