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Chemical strategies to overcome resistance against targeted anticancer therapeutics

Emergence of resistance is a major factor limiting the efficacy of molecularly targeted anticancer drugs. Understanding the specific mutations, or other genetic or cellular changes, that confer drug resistance can help in the development of therapeutic strategies with improved efficacies. Here, we o...

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Bibliografiske detaljer
Udgivet i:Nat Chem Biol
Main Authors: Pisa, Rudolf, Kapoor, Tarun M.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7510053/
https://ncbi.nlm.nih.gov/pubmed/32694636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0596-8
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