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Analyzing resistance to design selective chemical inhibitors for AAA proteins
Drug-like inhibitors are often designed by mimicking cofactor or substrate interactions with enzymes. However, as active sites are comprised of conserved residues, it is difficult to identify the critical interactions needed to design selective inhibitors. We are developing an approach, named RADD (...
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| Publicado no: | Cell Chem Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6754270/ https://ncbi.nlm.nih.gov/pubmed/31257183 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.06.001 |
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