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Distinct Mechanisms of Resistance to a CENPE Inhibitor Emerge in Near-Haploid and Diploid Cancer Cells
Aberrant chromosome numbers in cancer cells may impose distinct constraints on the emergence of drug resistance - a major factor limiting the long-term efficacy of molecularly-targeted therapeutics. However, for most anti-cancer drugs we lack analyses of drug resistance mechanisms in cells with diff...
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| Publicado no: | Cell Chem Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7444662/ https://ncbi.nlm.nih.gov/pubmed/32442423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.05.003 |
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