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Designing Allele-Specific Inhibitors of Spastin, a Microtubule-Severing AAA Protein
The bump–hole approach is a powerful chemical biology strategy to specifically probe the functions of closely related proteins. However, for many protein families, such as the ATPases associated with diverse cellular activities (AAA), we lack structural data for inhibitor-protein complexes to design...
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| Udgivet i: | J Am Chem Soc |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6637947/ https://ncbi.nlm.nih.gov/pubmed/30875216 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b13257 |
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