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Targeting BCL-2 in B-cell malignancies and overcoming therapeutic resistance
Defects in apoptosis can promote tumorigenesis and impair responses of malignant B cells to chemotherapeutics. Members of the B-cell leukemia/lymphoma-2 (BCL-2) family of proteins are key regulators of the intrinsic, mitochondrial apoptotic pathway. Overexpression of antiapoptotic BCL-2 family prote...
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| Publicado no: | Cell Death Dis |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7608616/ https://ncbi.nlm.nih.gov/pubmed/33139702 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03144-y |
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