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Leveraging Chemotype-specific Resistance for Drug Target Identification and Chemical Biology
Identifying the direct physiological targets of drugs and chemical probes remains challenging. Here we describe how resistance can be used to achieve ‘gold standard’ validation of a chemical inhibitor’s direct target in human cells. This involves demonstrating that a silent mutation in the target th...
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| Publicado no: | Trends Pharmacol Sci |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5708298/ https://ncbi.nlm.nih.gov/pubmed/29037508 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2017.09.003 |
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