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Epitope and Paratope Mapping of PD-1/Nivolumab by Mass Spectrometry-based Hydrogen/Deuterium Exchange, Cross-linking, and Molecular Docking
Programmed cell death-1 (PD-1), an antigen co-receptor on cell surfaces, is one of the conspicuous immune checkpoints. Nivolumab, a monoclonal antibody therapeutic approved by FDA, binds to PD-1 and efficiently blocks its pathways. In this study, an integrated approach was developed to map the epito...
Guardat en:
| Publicat a: | Anal Chem |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7501946/ https://ncbi.nlm.nih.gov/pubmed/32441507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.0c01291 |
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