Epitope and Paratope Mapping of PD-1/Nivolumab by Mass Spectrometry-based Hydrogen/Deuterium Exchange, Cross-linking, and Molecular Docking

Programmed cell death-1 (PD-1), an antigen co-receptor on cell surfaces, is one of the conspicuous immune checkpoints. Nivolumab, a monoclonal antibody therapeutic approved by FDA, binds to PD-1 and efficiently blocks its pathways. In this study, an integrated approach was developed to map the epito...

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Udgivet i:Anal Chem
Main Authors: Zhang, Mengru Mira, Huang, Richard Y.-C., Beno, Brett R., Deyanova, Ekaterina G., Li, Jing, Chen, Guodong, Gross, Michael L.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7501946/
https://ncbi.nlm.nih.gov/pubmed/32441507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.0c01291
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