Structure and mechanism of a dehydratase/decarboxylase enzyme couple involved in polyketide β-methyl branch incorporation

Complex polyketides of bacterial origin are biosynthesised by giant assembly-line like megaenzymes of the type 1 modular polyketide synthase (PKS) class. The trans-AT family of modular PKSs, whose biosynthetic frameworks diverge significantly from those of the archetypal cis-AT type systems represen...

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Pubblicato in:Sci Rep
Autori principali: Nair, Asha V., Robson, Alice, Ackrill, Thomas D., Till, Marisa, Byrne, Matthew J., Back, Catherine R., Tiwari, Kavita, Davies, Jonathan A., Willis, Christine L., Race, Paul R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7501309/
https://ncbi.nlm.nih.gov/pubmed/32948786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71850-w
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