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Mechanism of Intersubunit Ketosynthase-Dehydratase Interaction in Polyketide Synthases

Modular polyketide synthases (PKSs) produce numerous structurally complex natural products with diverse applications in medicine and agriculture. They typically consist of several multienzyme subunits that utilize structurally-defined docking domains (DDs) at their N- and C-termini to ensure correct...

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Publicat a:Nat Chem Biol
Autors principals: Jenner, Matthew, Kosol, Simone, Griffiths, Daniel, Prasongpholchai, Panward, Manzi, Lucio, Barrow, Andrew S., Moses, John E., Oldham, Neil J., Lewandowski, Józef R., Challis, Gregory L.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846730/
https://ncbi.nlm.nih.gov/pubmed/29309054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2549
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