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Mechanism of Intersubunit Ketosynthase-Dehydratase Interaction in Polyketide Synthases

Modular polyketide synthases (PKSs) produce numerous structurally complex natural products with diverse applications in medicine and agriculture. They typically consist of several multienzyme subunits that utilize structurally-defined docking domains (DDs) at their N- and C-termini to ensure correct...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Jenner, Matthew, Kosol, Simone, Griffiths, Daniel, Prasongpholchai, Panward, Manzi, Lucio, Barrow, Andrew S., Moses, John E., Oldham, Neil J., Lewandowski, Józef R., Challis, Gregory L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846730/
https://ncbi.nlm.nih.gov/pubmed/29309054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2549
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