Chromatin recruitment of OGG1 requires cohesin and mediator and is essential for efficient 8-oxoG removal

One of the most abundant DNA lesions induced by oxidative stress is the highly mutagenic 8-oxoguanine (8-oxoG), which is specifically recognized by 8-oxoguanine DNA glycosylase 1 (OGG1) to initiate its repair. How DNA glycosylases find small non-helix-distorting DNA lesions amongst millions of bases...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Lebraud, Emilie, Pinna, Guillaume, Siberchicot, Capucine, Depagne, Jordane, Busso, Didier, Fantini, Damiano, Irbah, Lamya, Robeska, Elena, Kratassiouk, Gueorgui, Ravanat, Jean-Luc, Epe, Bernd, Radicella, J Pablo, Campalans, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7498353/
https://ncbi.nlm.nih.gov/pubmed/32710616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa611
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