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Effect of single mutations in the OGG1 gene found in human tumors on the substrate specificity of the Ogg1 protein
We have investigated the effect of single amino acid substitutions of conserved arginines on the catalytic activities of the human Ogg1 protein (α-hOgg1-Ser(326)) (wild-type α-hOgg1). Mutant forms of hOgg1 with mutations Arg(46)→Gln (α-hOgg1-Gln(46)) and Arg(154)→His (α-hOgg1-His(154)) have previous...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC102664/ https://ncbi.nlm.nih.gov/pubmed/10908322 |
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