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Lost in the Crowd: How Does Human 8-Oxoguanine DNA Glycosylase 1 (OGG1) Find 8-Oxoguanine in the Genome?

The most frequent DNA lesion resulting from an oxidative stress is 7,8-dihydro-8-oxoguanine (8-oxoG). 8-oxoG is a premutagenic base modification due to its capacity to pair with adenine. Thus, the repair of 8-oxoG is critical for the preservation of the genetic information. Nowadays, 8-oxoG is also...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: D’Augustin, Ostiane, Huet, Sébastien, Campalans, Anna, Radicella, Juan Pablo
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7664663/
https://ncbi.nlm.nih.gov/pubmed/33171795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21218360
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