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Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1)

The DNA base excision repair (BER) pathway, which utilizes DNA glycosylases to initiate repair of specific DNA lesions, is the major pathway for the repair of DNA damage induced by oxidation, alkylation, and deamination. Early results from clinical trials suggest that inhibiting certain enzymes in t...

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Библиографические подробности
Опубликовано в: :ACS Chem Biol
Главные авторы: Donley, Nathan, Jaruga, Pawel, Coskun, Erdem, Dizdaroglu, Miral, McCullough, Amanda K., Lloyd, R. Stephen
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894821/
https://ncbi.nlm.nih.gov/pubmed/26218629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00452
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