Structural and biochemical studies of a plant formamidopyrimidine-DNA glycosylase reveal why eukaryotic Fpg glycosylases do not excise 8-oxoguanine

Formamidopyrimidine-DNA glycosylase (Fpg; MutM) is a DNA repair enzyme widely distributed in bacteria. Fpg recognizes and excises oxidatively modified purines, 4,6-diamino-5-formamidopyrimidine, 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 8-oxoguanine (8-oxoG), with similar excision kinetics. It...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Duclos, Stéphanie, Aller, Pierre, Jaruga, Pawel, Dizdaroglu, Miral, Wallace, Susan S., Doublié, Sylvie
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419285/
https://ncbi.nlm.nih.gov/pubmed/22789755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2012.06.004
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