Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase

OGG1 initiated base excision repair (BER) is the major pathway for repair of oxidative DNA base damage 8-oxoguanine (8-oxoG). Here, we report that RECQL4 DNA helicase, deficient in the cancer-prone and premature aging Rothmund-Thomson syndrome, physically and functionally interacts with OGG1. RECQL4...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Duan, Shunlei, Han, Xuerui, Akbari, Mansour, Croteau, Deborah L, Rasmussen, Lene Juel, Bohr, Vilhelm A
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Gene regulation, Chromatin and Epigenetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7337523/
https://ncbi.nlm.nih.gov/pubmed/32432680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa392
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