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The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients

RECQL4 is one of five members of the human RecQ helicase family, and is implicated in three syndromes displaying accelerating aging, developmental abnormalities and a predisposition to cancer. In this study, we purified three variants of RECQL4 carrying previously reported patient mutations. These t...

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Detalhes bibliográficos
Main Authors: Jensen, Martin Borch, Dunn, Christopher A., Keijzers, Guido, Kulikowicz, Tomasz, Rasmussen, Lene Juel, Croteau, Deborah L., Bohr, Vilhelm A.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3560432/
https://ncbi.nlm.nih.gov/pubmed/23238538
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