Potential role of polymorphisms in the transporter genes ENT1 and MATE1/OCT2 in predicting TAS-102 efficacy and toxicity in patients with refractory metastatic colorectal cancer

BACKGROUND: Trifluridine (FTD) is an active cytotoxic component of the metastatic colorectal cancer (mCRC) drug TAS-102, and thymidine phosphorylase inhibitor (TPI) inhibits the rapid degradation of FTD. We tested whether single nucleotide polymorphisms (SNPs) in genes involved in FTD metabolism and...

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Publicado no:Eur J Cancer
Main Authors: Suenaga, Mitsukuni, Schirripa, Marta, Cao, Shu, Zhang, Wu, Yang, Dongyun, Dadduzio, Vincenzo, Salvatore, Lisa, Borelli, Beatrice, Pietrantonio, Filippo, Ning, Yan, Okazaki, Satoshi, Berger, Martin D., Miyamoto, Yuji, Gopez, Roel, Barzi, Afsaneh, Yamaguchi, Toshiharu, Loupakis, Fotios, Lenz, Heinz-Josef
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7497848/
https://ncbi.nlm.nih.gov/pubmed/28992563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2017.08.033
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