Potential role of PIN1 genotypes in predicting benefit from oxaliplatin- and irinotecan-based treatment in patients with metastatic colorectal cancer

PIN1-mediated substrate isomerization plays a role in the repair of DNA double-strand breaks. We hypothesized that genetic polymorphisms in PIN1-related pathways may affect tumor sensitivity to oxaliplatin or irinotecan in metastatic colorectal cancer (mCRC) patients. We analyzed genomic DNA from fi...

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Gepubliceerd in:Pharmacogenomics J
Hoofdauteurs: Suenaga, Mitsukuni, Schirripa, Marta, Cao, Shu, Zhang, Wu, Yang, Dongyun, Cremolini, Chiara, Lonardi, Sara, Bergamo, Francesca, Ning, Yang, Yamamoto, Noriko, Okazaki, Satoshi, Berger, Martin D., Miyamoto, Yuji, Gopez, Roel, Barzi, Afsaneh, Yamaguchi, Toshiharu, Stintzing, Sebastian, Heinemann, Volker, Loupakis, Fotios, Falcone, Alfredo, Lenz, Heinz-Josef
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6151284/
https://ncbi.nlm.nih.gov/pubmed/29925895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41397-018-0030-8
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