Single nucleotide polymorphisms in the IGF-IRS pathway are associated with outcome in mCRC patients enrolled in the FIRE-3 trial

The Insulin-like growth factor (IGF)/IGF-receptor pathway with its scaffolding proteins Insulin Receptor Substrate (IRS)1 and IRS2 are crucial regulators of metabolism and progression in metastatic colorectal cancer (mCRC). The goal of the study was the identification of predictive and prognostic ma...

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Pubblicato in:Int J Cancer
Autori principali: Schirripa, Marta, Zhang, Wu, Heinemann, Volker, Cao, Shu, Okazaki, Satoshi, Yang, Dongyun, Loupakis, Fotios, Berger, Martin D., Ning, Yan, Miyamoto, Yuji, Suenaga, Mitsukuni, Gopez, Roel F., West, Jordan D., Hanna, Diana, Barzi, Afsaneh, Falcone, Alfredo, Stintzing, Sebastian, Lenz, Heinz-Josef
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510747/
https://ncbi.nlm.nih.gov/pubmed/28369940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.30715
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