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Genetic variants of DNA repair-related genes predict efficacy of TAS-102 in patients with refractory metastatic colorectal cancer
BACKGROUND: Tri-phosphorylated trifluridine (FTD) incorporation into DNA is TAS-102’s main anti-tumor action. We tested whether genetic polymorphisms in homologous recombination (HR) and cell cycle checkpoint pathway for DNA repair is associated with outcomes in refractory metastatic colorectal canc...
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| Publicado no: | Ann Oncol |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5834058/ https://ncbi.nlm.nih.gov/pubmed/28453695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdx035 |
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