Coevolution of Adeno-associated Virus Capsid Antigenicity and Tropism through a Structure-Guided Approach

Adeno-associated viruses (AAV) are composed of nonenveloped, icosahedral protein shells that can be adapted to package and deliver recombinant therapeutic DNA. Approaches to engineer recombinant capsids for gene therapy applications have focused on rational design or library-based approaches that ca...

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Detaylı Bibliyografya
Yayımlandı:J Virol
Asıl Yazarlar: Havlik, L. Patrick, Simon, Katherine E., Smith, J. Kennon, Klinc, Kelli A., Tse, Longping V., Oh, Daniel K., Fanous, Marco M., Meganck, Rita M., Mietzsch, Mario, Kleinschmidt, Jürgen, Agbandje-McKenna, Mavis, Asokan, Aravind
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2020
Konular:
Gene Delivery
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7495376/
https://ncbi.nlm.nih.gov/pubmed/32669336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00976-20
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