Structure-guided evolution of antigenically distinct adeno-associated virus variants for immune evasion

Preexisting neutralizing antibodies (NAbs) against adeno-associated viruses (AAVs) pose a major, unresolved challenge that restricts patient enrollment in gene therapy clinical trials using recombinant AAV vectors. Structural studies suggest that despite a high degree of sequence variability, antibo...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Tse, Longping Victor, Klinc, Kelli A., Madigan, Victoria J., Castellanos Rivera, Ruth M., Wells, Lindsey F., Havlik, L. Patrick, Smith, J. Kennon, Agbandje-McKenna, Mavis, Asokan, Aravind
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474820/
https://ncbi.nlm.nih.gov/pubmed/28559317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704766114
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