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Adeno-Associated Virus Type 2 Contains an Integrin α5β1 Binding Domain Essential for Viral Cell Entry

Integrins have been implicated as coreceptors in the infectious pathways of several nonenveloped viruses. For example, adenoviruses are known to interact with αV integrins by virtue of a high-affinity arginine-glycine-aspartate (RGD) domain present in the penton bases of the capsids. In the case of...

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Autores principales: Asokan, Aravind, Hamra, Julie B., Govindasamy, Lakshmanan, Agbandje-McKenna, Mavis, Samulski, Richard J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2006
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1563945/
https://ncbi.nlm.nih.gov/pubmed/16940508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00843-06
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