Single Amino Acid Changes Can Influence Titer, Heparin Binding, and Tissue Tropism in Different Adeno-Associated Virus Serotypes

Despite the high degree of sequence homology between adeno-associated virus (AAV) serotype 1 and 6 capsids (99.2%), these viruses have different liver transduction profiles when tested as vectors. Examination of the six amino acid residues that differ between AAV1 and AAV6 revealed that a lysine-to-...

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Main Authors: Wu, Zhijian, Asokan, Aravind, Grieger, Joshua C., Govindasamy, Lakshmanan, Agbandje-McKenna, Mavis, Samulski, R. Jude
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2006
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1642158/
https://ncbi.nlm.nih.gov/pubmed/16943302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01288-06
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