Heparin binding induces conformational changes in Adeno-associated virus serotype 2

Adeno-associated virus serotype 2 (AAV2) uses heparan sulfate proteoglycan as a cell surface-attachment receptor. In this study the structures of AAV2 alone and complexed with heparin were determined to ~18 Å resolution using cryo-electron microscopy and three-dimensional image reconstruction. A dif...

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Detalhes bibliográficos
Main Authors: Levy, Hazel C., Bowman, Valorie D., Govindasamy, Lakshmanan, McKenna, Robert, Nash, Kevin, Warrington, Kenneth, Chen, Weijun, Muzyczka, Nicholas, Yan, Xiaodong, Baker, Timothy S., Agbandje-McKenna, Mavis
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694330/
https://ncbi.nlm.nih.gov/pubmed/19121398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2008.12.002
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