Coevolution of Adeno-associated Virus Capsid Antigenicity and Tropism through a Structure-Guided Approach

Adeno-associated viruses (AAV) are composed of nonenveloped, icosahedral protein shells that can be adapted to package and deliver recombinant therapeutic DNA. Approaches to engineer recombinant capsids for gene therapy applications have focused on rational design or library-based approaches that ca...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Havlik, L. Patrick, Simon, Katherine E., Smith, J. Kennon, Klinc, Kelli A., Tse, Longping V., Oh, Daniel K., Fanous, Marco M., Meganck, Rita M., Mietzsch, Mario, Kleinschmidt, Jürgen, Agbandje-McKenna, Mavis, Asokan, Aravind
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Gene Delivery
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7495376/
https://ncbi.nlm.nih.gov/pubmed/32669336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00976-20
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