Single Amino Acid Modification of Adeno-Associated Virus Capsid Changes Transduction and Humoral Immune Profiles

Adeno-associated virus (AAV) vectors have the potential to promote long-term gene expression. Unfortunately, humoral immunity restricts patient treatment and in addition provides an obstacle to the potential option of vector readministration. In this study, we describe a comprehensive characterizati...

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Autores principales: Li, Chengwen, Diprimio, Nina, Bowles, Dawn E., Hirsch, Matthew L., Monahan, Paul E., Asokan, Aravind, Rabinowitz, Joseph, Agbandje-McKenna, Mavis, Samulski, R. Jude
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2012
Materias:
Gene Delivery
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421647/
https://ncbi.nlm.nih.gov/pubmed/22593151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00675-12
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