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α2,3 and α2,6 N-Linked Sialic Acids Facilitate Efficient Binding and Transduction by Adeno-Associated Virus Types 1 and 6

Recombinant adeno-associated viruses (AAVs) are promising vectors in the field of gene therapy. Different AAV serotypes display distinct tissue tropism, believed to be related to the distribution of their receptors on target cells. Of the 11 well-characterized AAV serotypes, heparan sulfate proteogl...

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Bibliografske podrobnosti
Main Authors: Wu, Zhijian, Miller, Edward, Agbandje-McKenna, Mavis, Samulski, Richard Jude
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2006
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1563919/
https://ncbi.nlm.nih.gov/pubmed/16940521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00895-06
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