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α2,3 and α2,6 N-Linked Sialic Acids Facilitate Efficient Binding and Transduction by Adeno-Associated Virus Types 1 and 6

Recombinant adeno-associated viruses (AAVs) are promising vectors in the field of gene therapy. Different AAV serotypes display distinct tissue tropism, believed to be related to the distribution of their receptors on target cells. Of the 11 well-characterized AAV serotypes, heparan sulfate proteogl...

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Библиографические подробности
Главные авторы: Wu, Zhijian, Miller, Edward, Agbandje-McKenna, Mavis, Samulski, Richard Jude
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2006
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1563919/
https://ncbi.nlm.nih.gov/pubmed/16940521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00895-06
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