Cytotoxic-T-Lymphocyte-Mediated Elimination of Target Cells Transduced with Engineered Adeno-Associated Virus Type 2 Vector In Vivo

A recent clinical trial in patients with hemophilia B has suggested that adeno-associated virus (AAV) capsid-specific cytotoxic T lymphocytes (CTLs) eliminated AAV-transduced hepatocytes and resulted in therapeutic failure. AAV capsids elicit a CTL response in animal models; however, these capsid-sp...

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Bibliographic Details
Main Authors: Li, Chengwen, Hirsch, Matt, DiPrimio, Nina, Asokan, Aravind, Goudy, Kevin, Tisch, Roland, Samulski, R. Jude
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Gene Delivery
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698563/
https://ncbi.nlm.nih.gov/pubmed/19369348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00278-09
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