Adeno-associated Virus (AAV) Capsid Chimeras with Enhanced Infectivity Reveal a Core Element in the AAV Genome Critical for both Cell Transduction and Capsid Assembly

Adeno-associated viruses (AAVs) have attracted significant attention in the field of gene and cell therapy due to their use in highly effective delivery of therapeutic genes into human cells. The ability to generate recombinant AAV (rAAV) vectors comprising unique or substituted protein sequences ha...

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Dades bibliogràfiques
Publicat a:J Virol
Autors principals: Viney, Lydia, Bürckstümmer, Tilmann, Eddington, Courtnee, Mietzsch, Mario, Choudhry, Modassir, Henley, Tom, Agbandje-McKenna, Mavis
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2021
Matèries:
Gene Delivery
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092683/
https://ncbi.nlm.nih.gov/pubmed/33441336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02023-20
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