Adeno-associated Virus (AAV) Capsid Chimeras with Enhanced Infectivity Reveal a Core Element in the AAV Genome Critical for both Cell Transduction and Capsid Assembly

Adeno-associated viruses (AAVs) have attracted significant attention in the field of gene and cell therapy due to their use in highly effective delivery of therapeutic genes into human cells. The ability to generate recombinant AAV (rAAV) vectors comprising unique or substituted protein sequences ha...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Viney, Lydia, Bürckstümmer, Tilmann, Eddington, Courtnee, Mietzsch, Mario, Choudhry, Modassir, Henley, Tom, Agbandje-McKenna, Mavis
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2021
Fag:
Gene Delivery
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092683/
https://ncbi.nlm.nih.gov/pubmed/33441336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02023-20
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