A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis

Frequent mutation of the tumour suppressor RNF43 is observed in many cancers, particularly colon malignancies. RNF43, an E3 ubiquitin ligase, negatively regulates Wnt signalling by inducing degradation of the Wnt receptor Frizzled. In this study, we discover that RNF43 activity requires phosphorylat...

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Publicado no:Nat Commun
Main Authors: Tsukiyama, Tadasuke, Zou, Juqi, Kim, Jihoon, Ogamino, Shohei, Shino, Yuki, Masuda, Takamasa, Merenda, Alessandra, Matsumoto, Masaki, Fujioka, Yoichiro, Hirose, Tomonori, Terai, Sayuri, Takahashi, Hidehisa, Ishitani, Tohru, Nakayama, Keiichi I., Ohba, Yusuke, Koo, Bon-Kyoung, Hatakeyama, Shigetsugu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7492264/
https://ncbi.nlm.nih.gov/pubmed/32934222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18257-3
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