A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis

Frequent mutation of the tumour suppressor RNF43 is observed in many cancers, particularly colon malignancies. RNF43, an E3 ubiquitin ligase, negatively regulates Wnt signalling by inducing degradation of the Wnt receptor Frizzled. In this study, we discover that RNF43 activity requires phosphorylat...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Tsukiyama, Tadasuke, Zou, Juqi, Kim, Jihoon, Ogamino, Shohei, Shino, Yuki, Masuda, Takamasa, Merenda, Alessandra, Matsumoto, Masaki, Fujioka, Yoichiro, Hirose, Tomonori, Terai, Sayuri, Takahashi, Hidehisa, Ishitani, Tohru, Nakayama, Keiichi I., Ohba, Yusuke, Koo, Bon-Kyoung, Hatakeyama, Shigetsugu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2020
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7492264/
https://ncbi.nlm.nih.gov/pubmed/32934222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18257-3
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