A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis

Frequent mutation of the tumour suppressor RNF43 is observed in many cancers, particularly colon malignancies. RNF43, an E3 ubiquitin ligase, negatively regulates Wnt signalling by inducing degradation of the Wnt receptor Frizzled. In this study, we discover that RNF43 activity requires phosphorylat...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Nat Commun
मुख्य लेखकों: Tsukiyama, Tadasuke, Zou, Juqi, Kim, Jihoon, Ogamino, Shohei, Shino, Yuki, Masuda, Takamasa, Merenda, Alessandra, Matsumoto, Masaki, Fujioka, Yoichiro, Hirose, Tomonori, Terai, Sayuri, Takahashi, Hidehisa, Ishitani, Tohru, Nakayama, Keiichi I., Ohba, Yusuke, Koo, Bon-Kyoung, Hatakeyama, Shigetsugu
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group UK 2020
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7492264/
https://ncbi.nlm.nih.gov/pubmed/32934222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18257-3
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