Leukemogenic kinase FIP1L1‐PDGFRA and a small ubiquitin‐like modifier E3 ligase, PIAS1, form a positive cross‐talk through their enzymatic activities

Fusion tyrosine kinases play a crucial role in the development of hematological malignancies. FIP1L1‐PDGFRA is a leukemogenic fusion kinase that causes chronic eosinophilic leukemia. As a constitutively active kinase, FIP1L1‐PDGFRA stimulates downstream signaling molecules, leading to cellular proli...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Ibata, Makoto, Iwasaki, Junko, Fujioka, Yoichiro, Nakagawa, Koji, Darmanin, Stephanie, Onozawa, Masahiro, Hashimoto, Daigo, Ohba, Yusuke, Hatakeyama, Shigetsugu, Teshima, Takanori, Kondo, Takeshi
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5367148/
https://ncbi.nlm.nih.gov/pubmed/27960034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13129
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