Ageing compromises mouse thymus function and remodels epithelial cell differentiation

Ageing is characterised by cellular senescence, leading to imbalanced tissue maintenance, cell death and compromised organ function. This is first observed in the thymus, the primary lymphoid organ that generates and selects T cells. However, the molecular and cellular mechanisms underpinning these...

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Foilsithe in:eLife
Main Authors: Baran-Gale, Jeanette, Morgan, Michael D, Maio, Stefano, Dhalla, Fatima, Calvo-Asensio, Irene, Deadman, Mary E, Handel, Adam E, Maynard, Ashley, Chen, Steven, Green, Foad, Sit, Rene V, Neff, Norma F, Darmanis, Spyros, Tan, Weilun, May, Andy P, Marioni, John C, Ponting, Chris P, Holländer, Georg A
Formáid: Artigo
Teanga:Inglês
Foilsithe: eLife Sciences Publications, Ltd 2020
Ábhair:
Immunology and Inflammation
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7490013/
https://ncbi.nlm.nih.gov/pubmed/32840480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56221
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