Ageing compromises mouse thymus function and remodels epithelial cell differentiation

Ageing is characterised by cellular senescence, leading to imbalanced tissue maintenance, cell death and compromised organ function. This is first observed in the thymus, the primary lymphoid organ that generates and selects T cells. However, the molecular and cellular mechanisms underpinning these...

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Pubblicato in:eLife
Autori principali: Baran-Gale, Jeanette, Morgan, Michael D, Maio, Stefano, Dhalla, Fatima, Calvo-Asensio, Irene, Deadman, Mary E, Handel, Adam E, Maynard, Ashley, Chen, Steven, Green, Foad, Sit, Rene V, Neff, Norma F, Darmanis, Spyros, Tan, Weilun, May, Andy P, Marioni, John C, Ponting, Chris P, Holländer, Georg A
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2020
Soggetti:
Immunology and Inflammation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7490013/
https://ncbi.nlm.nih.gov/pubmed/32840480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56221
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