The Alzheimer’s disease-associated protective Plcγ2-P522R variant promotes immune functions

BACKGROUND: Microglia-specific genetic variants are enriched in several neurodegenerative diseases, including Alzheimer’s disease (AD), implicating a central role for alterations of the innate immune system in the disease etiology. A rare coding variant in the PLCG2 gene (rs72824905, p.P522R) expres...

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Dettagli Bibliografici
Pubblicato in:Mol Neurodegener
Autori principali: Takalo, Mari, Wittrahm, Rebekka, Wefers, Benedikt, Parhizkar, Samira, Jokivarsi, Kimmo, Kuulasmaa, Teemu, Mäkinen, Petra, Martiskainen, Henna, Wurst, Wolfgang, Xiang, Xianyuan, Marttinen, Mikael, Poutiainen, Pekka, Haapasalo, Annakaisa, Hiltunen, Mikko, Haass, Christian
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
Soggetti:
Short Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488484/
https://ncbi.nlm.nih.gov/pubmed/32917267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-020-00402-7
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