MECP2 Increases the Pro-Inflammatory Response of Microglial Cells and Phosphorylation at Serine 423 Regulates Neuronal Gene Expression upon Neuroinflammation

Methyl-CpG-binding protein 2 (MECP2) is a critical transcriptional regulator for synaptic function. Dysfunction of synapses, as well as microglia-mediated neuroinflammation, represent the earliest pathological events in Alzheimer’s disease (AD). Here, expression, protein levels, and activity-related...

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Publié dans:Cells
Auteurs principaux: Wittrahm, Rebekka, Takalo, Mari, Marttinen, Mikael, Kuulasmaa, Teemu, Mäkinen, Petra, Kemppainen, Susanna, Martiskainen, Henna, Rauramaa, Tuomas, Pike, Ian, Leinonen, Ville, Natunen, Teemu, Haapasalo, Annakaisa, Hiltunen, Mikko
Format: Artigo
Langue:Inglês
Publié: MDPI 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8070522/
https://ncbi.nlm.nih.gov/pubmed/33918872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10040860
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