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SIRT3 deficiency exacerbates fatty liver by attenuating the HIF1α-LIPIN 1 pathway and increasing CD36 through Nrf2
BACKGROUND: Deficiency of mitochondrial sirtuin 3 (SIRT3), a NAD(+)-dependent protein deacetylase that maintains redox status and lipid homeostasis, contributes to hepatic steatosis. In this study, we investigated additional mechanisms that might play a role in aggravating hepatic steatosis in Sirt3...
Shranjeno v:
| izdano v: | Cell Commun Signal |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
BioMed Central
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7488148/ https://ncbi.nlm.nih.gov/pubmed/32912335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-00640-8 |
| Oznake: |
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