SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation

Sirtuin 3 (SIRT3) is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress. Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances. In this study, we invest...

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Publicat a:Signal Transduct Target Ther
Autors principals: Palomer, Xavier, Román-Azcona, M. Silvia, Pizarro-Delgado, Javier, Planavila, Ana, Villarroya, Francesc, Valenzuela-Alcaraz, Brenda, Crispi, Fátima, Sepúlveda-Martínez, Álvaro, Miguel-Escalada, Irene, Ferrer, Jorge, Nistal, J. Francisco, García, Raquel, Davidson, Mercy M., Barroso, Emma, Vázquez-Carrera, Manuel
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7046732/
https://ncbi.nlm.nih.gov/pubmed/32296036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-020-0114-1
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