SIRT3 DEACETYLATES AND INCREASES PYRUVATE DEHYDROGENASE ACTIVITY IN CANCER CELLS

Pyruvate dehydrogenase E1 alpha (PDHE1α or PDHA1) is the first component enzyme of the pyruvate dehydrogenase (PDH) complex (PDC) that transforms pyruvate, via pyruvate decarboxylation, into acetyl-CoA that is subsequently used by both the citric acid cycle and oxidative phosphorylation to generate...

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Detalhes bibliográficos
Publicado no:Free Radic Biol Med
Main Authors: Ozden, Ozkan, Park, Seong-Hoon, Wagner, Brett A., Song, Ha Yong, Zhu, Yueming, Vassilopoulos, Athanassios, Jung, Barbara, Buettner, Garry R., Gius, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364304/
https://ncbi.nlm.nih.gov/pubmed/25152236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2014.08.001
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