SIRT3 DEACETYLATES AND INCREASES PYRUVATE DEHYDROGENASE ACTIVITY IN CANCER CELLS

Pyruvate dehydrogenase E1 alpha (PDHE1α or PDHA1) is the first component enzyme of the pyruvate dehydrogenase (PDH) complex (PDC) that transforms pyruvate, via pyruvate decarboxylation, into acetyl-CoA that is subsequently used by both the citric acid cycle and oxidative phosphorylation to generate...

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Bibliografiset tiedot
Julkaisussa:Free Radic Biol Med
Päätekijät: Ozden, Ozkan, Park, Seong-Hoon, Wagner, Brett A., Song, Ha Yong, Zhu, Yueming, Vassilopoulos, Athanassios, Jung, Barbara, Buettner, Garry R., Gius, David
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364304/
https://ncbi.nlm.nih.gov/pubmed/25152236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2014.08.001
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