SIRT2-mediated deacetylation and tetramerization of pyruvate kinase directs glycolysis and tumor growth

Sirtuins participate in sensing nutrient availability and directing metabolic activity to match energy needs with energy production and consumption. However, the pivotal targets for sirtuins in cancer are mainly unknown. In this study, we identify the M2 isoform of pyruvate kinase (PKM2) as a critic...

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Detaylı Bibliyografya
Yayımlandı:Cancer Res
Asıl Yazarlar: Park, Seong-Hoon, Ozden, Ozkan, Liu, Guoxiang, Song, Ha Yong, Zhu, Yueming, Yan, Yufan, Zou, Xianghui, Kang, Hong-Jun, Jiang, Haiyan, Principe, Daniel R., Cha, Yong-Il, Roh, Meejeon, Vassilopoulos, Athanassios, Gius, David
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4930699/
https://ncbi.nlm.nih.gov/pubmed/27197174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2498
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