SIRT2-mediated deacetylation and tetramerization of pyruvate kinase directs glycolysis and tumor growth

Sirtuins participate in sensing nutrient availability and directing metabolic activity to match energy needs with energy production and consumption. However, the pivotal targets for sirtuins in cancer are mainly unknown. In this study, we identify the M2 isoform of pyruvate kinase (PKM2) as a critic...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Cancer Res
Главные авторы: Park, Seong-Hoon, Ozden, Ozkan, Liu, Guoxiang, Song, Ha Yong, Zhu, Yueming, Yan, Yufan, Zou, Xianghui, Kang, Hong-Jun, Jiang, Haiyan, Principe, Daniel R., Cha, Yong-Il, Roh, Meejeon, Vassilopoulos, Athanassios, Gius, David
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4930699/
https://ncbi.nlm.nih.gov/pubmed/27197174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2498
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы