SIRT2-mediated deacetylation and tetramerization of pyruvate kinase directs glycolysis and tumor growth

Sirtuins participate in sensing nutrient availability and directing metabolic activity to match energy needs with energy production and consumption. However, the pivotal targets for sirtuins in cancer are mainly unknown. In this study, we identify the M2 isoform of pyruvate kinase (PKM2) as a critic...

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Détails bibliographiques
Publié dans:Cancer Res
Auteurs principaux: Park, Seong-Hoon, Ozden, Ozkan, Liu, Guoxiang, Song, Ha Yong, Zhu, Yueming, Yan, Yufan, Zou, Xianghui, Kang, Hong-Jun, Jiang, Haiyan, Principe, Daniel R., Cha, Yong-Il, Roh, Meejeon, Vassilopoulos, Athanassios, Gius, David
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4930699/
https://ncbi.nlm.nih.gov/pubmed/27197174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2498
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